exposure and long-acting agents.
That said, other analyses suggest the relationship may be confounded by prodromal symptoms (early anxiety/sleep changes before dementia is diagnosed). After accounting for this “reverse causality,” some studies found no significant association. The safest interpretation today: use the lowest dose for the shortest time, avoid chronic use when possible, and consider non-drug therapies for sleep and anxiety.
Do Acid Reflux Drugs (PPIs) Raise Risk Too?
In 2016, a German cohort study reported that regular proton-pump inhibitor (PPI) use (e.g., omeprazole, esomeprazole) was associated with
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